A blood cell disorder is a condition in which there’s a problem with your red blood cells, white blood cells, or the smaller circulating cells called platelets, which are critical for clot formation. All three cell types form in the bone marrow, which is the soft tissue inside your bones. Red blood cells transport oxygen to your body’s organs and tissues. White blood cells help your body fight infections. Platelets help your blood to clot. Blood cell disorders impair the formation and function of one or more of these types of blood cells.
Symptoms will vary depending on the type of blood cell disorder. Common symptoms of red blood cell disorders are:
Common symptoms of white blood cell disorders are:
Common symptoms of platelet disorders are:
There are many types of blood cell disorders that can greatly affect your overall health.
Red blood cell disorders affect the body’s red blood cells. These are cells in your blood that carry oxygen from your lungs to the rest of your body. There are a variety of these disorders, which can affect both children and adults.
Anemia
Anemia is one type of red blood cell disorder. A lack of the mineral iron in your blood commonly causes this disorder. Your body needs iron to produce the protein hemoglobin, which helps your red blood cells (RBCs) carry oxygen from your lungs to the rest of your body. There are many types of anemia.
Thalassemia is a group of inherited blood disorders. These disorders are caused by genetic mutations that prevent the normal production of hemoglobin. When red blood cells do not have enough hemoglobin, oxygen doesn’t get to all parts of the body. Organs then do not function properly. These disorders can result in:
Polycythemia is a blood cancer caused by a gene mutation. If you have polycythemia, your bone marrow makes too many red blood cells. This causes your blood to thicken and flow more slowly, putting you at risk for blood clots that can cause heart attacks or strokes. There is no known cure. Treatment involves phlebotomy, or removing blood from your veins, and medication.
White blood cells (leukocytes) help defend the body against infection and foreign substances. White blood cell disorders can affect your body’s immune response and your body’s ability to fight off infection. These disorders can affect both adults and children.
Lymphoma
Lymphoma is a blood cancer that occurs in the body’s lymphatic system. Your white blood cells change and grow out of control. Hodgkin’s lymphoma and non-Hodgkin’s lymphoma are the two major types of lymphoma.
Leukemia
Leukemia is blood cancer in which malignant white blood cells multiply inside your body’s bone marrow. Leukemia may be either acute or chronic. Chronic leukemia advances more slowly.
Myelodysplastic syndrome (MDS)
Myelodysplastic syndrome (MDS) is a condition affecting the white blood cells in your bone marrow. The body produces too many immature cells, called blasts. The blasts multiply and crowd out the mature and healthy cells. Myelodysplastic syndrome may progress either slowly or quite fast. It sometimes leads to leukemia.
Platelet Disorders
Blood platelets are the first responders when you have a cut or other injury. They gather at the site of the injury, creating a temporary plug to stop blood loss. If you have a platelet disorder, your blood has one of three abnormalities:
Platelet disorders are primarily genetic, meaning they are inherited. Some of these disorders include:
Von Willebrand disease
Von Willebrand disease is the most common inherited bleeding disorder. It is caused by a deficiency of a protein that helps your blood clot, called von Willebrand factor (VWF).
Hemophilia
Hemophilia is probably the best-known blood clotting disorder. It occurs almost always in males. The most serious complication of hemophilia is excessive and prolonged bleeding. This bleeding can be either inside or outside your body. The bleeding can start for no apparent reason. Treatment involves a hormone called desmopressin for mild type A, which can promote release of more of the reduced clotting factor, and infusions of blood or plasma for types B and C.
Primary thrombocythemia
Primary thrombocythemia is a rare disorder that can lead to increased blood clotting. This puts you at higher risk for stroke or heart attack. The disorder occurs when your bone marrow produces too many platelets.
Acquired platelet function disorders
Certain drugs and medical conditions can also affect the functioning of platelets. Be sure to coordinate all your medications with your doctor, even over-the-counter ones you choose yourself. The Canadian Hemophilia Association (CHA) warns that the following common drugs may affect platelets, especially if taken long-term.
There are a large variety of disorders that affect the plasma cells, the type of white blood cells in your body that make antibodies. These cells are very important to your body’s ability to ward off infection and disease.
Plasma cell myeloma
Plasma cell myeloma is a rare blood cancer that develops in the plasma cells in the bone marrow. Malignant plasma cells accumulate in the bone marrow and form tumors called plasmacytomas, generally in bones such as the spine, hips, or ribs. The abnormal plasma cells produce abnormal antibodies called monoclonal (M) proteins. These proteins build up in the bone marrow, crowding out the healthy proteins. This can lead to thickened blood and kidney damage. The cause of plasma cell myeloma is unknown.
Your doctor may order several tests, including a complete blood count (CBC) to see how many of each type of blood cell you have. Your doctor may also order a bone marrow biopsy to see if there are any abnormal cells developing in your marrow. This will involve removing a small amount of bone marrow for testing.
Your treatment plan depends on the cause of your illness, your age, and your overall health status. Your doctor may use a combination of treatments to help correct your blood cell disorder.
Medication
Some pharmacotherapy options include medications such as Nplate (romiplostim) to stimulate the bone marrow to produce more platelets in a platelet disorder. For white blood cell disorders, antibiotics can help fight infections. Dietary supplements such as iron and vitamin B-9 or B-12 can treat anemia due to deficiencies. Vitamin B-9 is also called folate, and vitamin B-12 is also known as cobalamin.
Surgery
Bone marrow transplants may repair or replace damaged marrow. These involve transferring stem cells, usually from a donor, to your body to help your bone marrow begin producing normal blood cells. A blood transfusion is another option to help you replace lost or damaged blood cells. During a blood transfusion, you receive an infusion of healthy blood from a donor.
Both procedures require specific criteria to succeed. Bone marrow donors must match or be as close as possible to your genetic profile. Blood transfusions require a donor with a compatible blood type.